Job summary
We are seeking a Clinical Research Fellow to join the Imperial Small Vessel Disease Research Group in the Department of Brain Sciences. This is an exciting opportunity to join our new research programme to establish the causes of cerebral small vessel disease. This is one of the commonest causes of stroke and dementia, but our understanding of the disease is limited and therefore we have no treatments.
Main duties of the job
Assist with recruitment, assessment (clinical and cognitive) and follow-up of patients as part of prospective cohort studies and randomised controlled trials.
Manage and supervise research MRI scanning, including respiratory gas challenges.
Train to perform physiological assessments independently, including transcranial ultrasound.
Develop skills in analysis of physiological data, MRI imaging and statistical analysis of large datasets.
Manage own research and administrative activities, within guidelines provided by senior colleagues.
Publish research papers in peer-reviewed journals.
Attend and present work at international conferences.
To develop a personal programme of research, developing research proposals and funding bids and being successfully awarded them.
To take initiatives in the planning and leading of research.
Contribute to wider project planning, including ideas for new research projects.
To direct the work of small research teams, supervising and taking responsibility for the research team (for post-doctoral applicants).
Supervise research assistants, masters, and PhD students (for post-doctoral applicants).
Teach undergraduate and postgraduate courses as needed.
To undertake appropriate administration tasks
To attend relevant meetings
To undertake any necessary training and/or development
About us
The post is funded by the St Mary's Development Trust to investigate the causes of cerebral small vessel disease and to develop new treatments. Chronic damage to the small blood vessels in the brain results in 40% of dementia, 30% of strokes and 80% of bleeds in the brain. However, it presents with a wide range of clinical and imaging presentations whilst the dysfunction of the blood vessels at the heart of the disease remains poorly understood. As a result, we have poor understanding of the underlying mechanisms and no current treatments. The successful candidate will join a newly established research program that aims to understand the mechanisms of this disease, develop better methods of measuring it and identify new treatments.
The Imperial Small Vessel Disease Research Group is establishing a new research programme incorporating studies in 'Big Data,' MRI imaging, prospective cohort studies and phase 2 clinical trials. This role will cover the breadth of these studies, with a particular focus on our novel, all-inclusive cohort of patients with cerebral small vessel disease (ACCESS@ICL) undergoing detailed clinical, functional and physiological assessments.
Job description
Job responsibilities
Job summary
We are seeking a Clinical Research Fellow to join the Imperial Small Vessel Disease Research Group in the Department of Brain Sciences. This is an exciting opportunity to join our new research programme to establish the causes of cerebral small vessel disease. This is one of the commonest causes of stroke and dementia, but our understanding of the disease is limited and therefore we have no treatments. The group combines studies in Big Data analysis, MRI imaging, clinical and physiological cohorts and clinical trials to understand why the disease is so variable, what the underlying pathways are and therefore how to treat it.
This key role will lead recruitment and assessment of patients in our clinical cohort and future clinical trials, including clinical, cognitive and functional assessment. You will learn and perform physiological assessments including transcranial Doppler and cardiovascular physiology, as well as MRI imaging studies including respiratory gas challenges. In addition to supporting the core patient-facing work of the programme, you will be expected to develop your own research project within the programme with opportunities either to focus on analysis of MRI imaging to define patterns of small vessel disease, or to define the cardiovascular physiological basis of small vessel disease and how this relates to clinical and imaging markers of the disease, depending on prior skills and aptitude.
The post is ideal for doctors with a clinical interest and experience in neurology, stroke or geratology who have completed Foundation and core training, and are either in a training post (ST3-5) or ready for one. Research experience in this field is desirable but not essential and the post is suitable either for pre-doctoral clinical fellows interested in developing a research proposal to apply for a PhD and fellowship funding, or for post-doctoral clinical academics in this area looking for further research experience and aiming to build a research proposal for intermediate or advanced fellowships.
This is a full-time post which is advertised for 2 years in the first instance, but with a view to additional direct support after this time or identification of independent funding opportunities. The post is a full-time research position, but flexible working options will be readily considered, whilst opportunities to maintain clinical skills through neurology or the acute stroke service at Charing Cross may be available.
Duties and responsibilities
Lead recruitment, assessment, and follow-up of patients as part of prospective cohort studies and randomised controlled trials.Train to perform physiological assessments such as transcranial ultrasound, and to manage and supervise research MRI scanning, including gas challenges.Develop skills in analysis of physiological data, MRI imaging and statistical analysis of large datasets.Manage own research and administrative activities.Publish research papers in peer-reviewed journals.Attend and present work at international conferences.
Essential requirements
Medically qualified (MBBS or equivalent) with GMC registration and a licence to practice.Completion of Foundation Training, ideally with clinical experience consistent with specialty training in neurology, stroke or geratology (ST3-5).Excellent communication skills with a wide range of peopleAbility to organise own work with minimal supervision.Good computer skills, including word-processing, spreadsheets and the Internet.
Further information
This is a fixed term position for 2 years, between 1/10/2024 and 30/09/2026, depending on previous experience, with the potential for extension of the position or support to apply for further research training.
This role includes engagement with patients and handling of human samples. A criminal records check and appropriate vaccinations will be required.
Should you require any further details on the role please contact: Dr Alastair Webb, alastair.webb@imperial.ac.uk
Hybrid working may be considered for this role. Staff working in roles that are suitable for hybrid working will normally be expected to work 60% of their time onsite. The opportunity for hybrid working will be discussed at interview.
More information is available on the following web page: Work Location Framework | Administration and support services | Imperial College London
Job description
Job responsibilities
Job summary
We are seeking a Clinical Research Fellow to join the Imperial Small Vessel Disease Research Group in the Department of Brain Sciences. This is an exciting opportunity to join our new research programme to establish the causes of cerebral small vessel disease. This is one of the commonest causes of stroke and dementia, but our understanding of the disease is limited and therefore we have no treatments. The group combines studies in Big Data analysis, MRI imaging, clinical and physiological cohorts and clinical trials to understand why the disease is so variable, what the underlying pathways are and therefore how to treat it.
This key role will lead recruitment and assessment of patients in our clinical cohort and future clinical trials, including clinical, cognitive and functional assessment. You will learn and perform physiological assessments including transcranial Doppler and cardiovascular physiology, as well as MRI imaging studies including respiratory gas challenges. In addition to supporting the core patient-facing work of the programme, you will be expected to develop your own research project within the programme with opportunities either to focus on analysis of MRI imaging to define patterns of small vessel disease, or to define the cardiovascular physiological basis of small vessel disease and how this relates to clinical and imaging markers of the disease, depending on prior skills and aptitude.
The post is ideal for doctors with a clinical interest and experience in neurology, stroke or geratology who have completed Foundation and core training, and are either in a training post (ST3-5) or ready for one. Research experience in this field is desirable but not essential and the post is suitable either for pre-doctoral clinical fellows interested in developing a research proposal to apply for a PhD and fellowship funding, or for post-doctoral clinical academics in this area looking for further research experience and aiming to build a research proposal for intermediate or advanced fellowships.
This is a full-time post which is advertised for 2 years in the first instance, but with a view to additional direct support after this time or identification of independent funding opportunities. The post is a full-time research position, but flexible working options will be readily considered, whilst opportunities to maintain clinical skills through neurology or the acute stroke service at Charing Cross may be available.
Duties and responsibilities
Lead recruitment, assessment, and follow-up of patients as part of prospective cohort studies and randomised controlled trials.Train to perform physiological assessments such as transcranial ultrasound, and to manage and supervise research MRI scanning, including gas challenges.Develop skills in analysis of physiological data, MRI imaging and statistical analysis of large datasets.Manage own research and administrative activities.Publish research papers in peer-reviewed journals.Attend and present work at international conferences.
Essential requirements
Medically qualified (MBBS or equivalent) with GMC registration and a licence to practice.Completion of Foundation Training, ideally with clinical experience consistent with specialty training in neurology, stroke or geratology (ST3-5).Excellent communication skills with a wide range of peopleAbility to organise own work with minimal supervision.Good computer skills, including word-processing, spreadsheets and the Internet.
Further information
This is a fixed term position for 2 years, between 1/10/2024 and 30/09/2026, depending on previous experience, with the potential for extension of the position or support to apply for further research training.
This role includes engagement with patients and handling of human samples. A criminal records check and appropriate vaccinations will be required.
Should you require any further details on the role please contact: Dr Alastair Webb, alastair.webb@imperial.ac.uk
Hybrid working may be considered for this role. Staff working in roles that are suitable for hybrid working will normally be expected to work 60% of their time onsite. The opportunity for hybrid working will be discussed at interview.
More information is available on the following web page: Work Location Framework | Administration and support services | Imperial College London
Person Specification
Qualifications
Essential
- Medically qualified (MBBS or equivalent)
- GMC Registration with licence to practice
- Completion of Foundation and Core Training or equivalent (eg ST3-ST5)
- MRCP or equivalent
Desirable
- PhD in a closely related discipline, or equivalent research, industrial or commercial experience
Experience
Essential
- Strong background in neurology, stroke, old age medicine or general medicine.
- Knowledge of research methods and statistical procedures
- Evidence of teaching and teaching support
Desirable
- Experience within research environment
- Experience of cardiovascular physiological testing
- Experience of recruiting to clinical studies
- Experience of MRI scanning
- A record of high-quality publications in international peer-reviewed journals
- Experience of analytical software / coding, eg R, python, matlab, SPSS, STATA
- Experience of the supervision of research of undergraduate/postgraduate students
- Experience of presenting results and findings to specialist audiences
Person Specification
Qualifications
Essential
- Medically qualified (MBBS or equivalent)
- GMC Registration with licence to practice
- Completion of Foundation and Core Training or equivalent (eg ST3-ST5)
- MRCP or equivalent
Desirable
- PhD in a closely related discipline, or equivalent research, industrial or commercial experience
Experience
Essential
- Strong background in neurology, stroke, old age medicine or general medicine.
- Knowledge of research methods and statistical procedures
- Evidence of teaching and teaching support
Desirable
- Experience within research environment
- Experience of cardiovascular physiological testing
- Experience of recruiting to clinical studies
- Experience of MRI scanning
- A record of high-quality publications in international peer-reviewed journals
- Experience of analytical software / coding, eg R, python, matlab, SPSS, STATA
- Experience of the supervision of research of undergraduate/postgraduate students
- Experience of presenting results and findings to specialist audiences
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
Additional information
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
