Job summary
This position is not suitable for applicants on the MTI scheme.
If you are interested in working for us via the MTI route, please refer to our position, reference number 413-C2022-22700
This is an exceptional opportunity in the ECMT. We seek an ambitious, innovative individual to provide medical support to the consultants by primarily acting as co-investigator on a growing portfolio of Phase I clinical trials.
The role offers an exciting opportunity to join a highly motivated & empowered workforce to increase research capacity & deliver innovative early phase research in compliance with Good Clinical Practice & Trust policy. With consultant oversight, you will be responsible for seeing new referrals, follow-ups & for managing the patient throughout all aspects of their trial experience. ECMT has a well-established and regular molecular tumour board meeting supporting both local and national studies. You will take an active in these meetings gaining valuable experience in using these data to identify and define suitable trial options for patients. You will have the opportunity to be involved in audit, writing papers and reviews and there is the potential to present research work at local, national, or international meetings.
The position is suitable for individuals who wish to gain further experience in experimental medicine & Phase I trials, including first-in-human trials, clinical pharmacology trials & translational research.
Main duties of the job
A diverse range of clinical research trials are in progress & following training, you will be expected to participate in these studies as a co-/sub-investigator. These include Phase I trials of small molecule inhibitors, next-generation chemotherapy trials, combination / multi-modality Phase I trials, molecular characterisation / translational studies.
You will be involved in managing all aspects of trial patients (both in outpatient & in-patients setting), across a diverse range of solid tumours, through new patient consultation, consent & screening patients & reviewing patients at follow-up appointments.
You will be expected to attend Safety Review Committee meetings (usually remotely) to discuss trial patients. This will involve close liaison with the Principal Investigators, referring consultant body across the Trust & other members of the team. In addition, the post-holder will interface with external stakeholders such as CROs & pharmaceutical sponsors.
The post-holder will be expected to attend monthly molecular tumour board meetings to discuss trial patients and to agree opportunities for patients to enrol in early phase trials.
You will be expected to undertake the administrative duties associated with the care of their patients. The appointee will be encouraged to be involved in the development & planning of new studies.
About us
The Experimental Cancer Medicine Team (ECMT) is specifically designed to facilitate early phase research. Facilities include inpatient beds, outpatient suites, trials pharmacy, laboratory & an administrative floor. The close links with the Cancer Research UK MI provide GCLP compliant laboratories.
The remit of the ECMT is to undertake cutting edge research in developing new therapeutics & conducting translational cancer research. Phase I trials are an important first step in the drug development process & are not only designed to test the safety & tolerability of novel agents but interrogate new drug formulations, combinations, pharmacokinetics & pharmacodynamics.
You will be based within ECMT, providing medical support to the consultants by primarily acting as co-investigator on Phase I clinical trials. With consultant oversight, you will be responsible for seeing new referrals, follow-ups & for managing the patient throughout all aspects of their trial experience. They will join a highly motivated & empowered workforce to increase research capacity & deliver innovative early phase research in compliance with Good Clinical Practice, Trust policy & other relevant requirements.
Job description
Job responsibilities
This is a 10 session non-training post (on the salary scale MN37, point dependent on experience) funded through The Christie NHS Foundation Trust for an initial period of 1 year (potential to extend to 2 years). The Senior Clinical fellow role is suitable for individuals towards the end of, or having completed, their specialist oncology training who wish to gain further experience in experimental medicine and Phase I trials, including first-in-human trials, clinical pharmacology trials and translational research. You will work with the experimental medicine consultants Dr Natalie Cook,Prof. Fiona Thistlethwaite, Dr Louise Carter, Dr Matt Krebs, and Dr Donna Graham, research nurses, Clinical Trials Coordinators, Translational Research Technician, secretarial support, as well as working alongside rotating clinical fellows and specialty trainees. The team is supported by medical and clinical oncology colleagues in all major tumour types.The position requires an ability to understand and deliver experimental clinical research, liaising across a range of clinical, academic and administrative staff throughout the Trust and with external organisations (pharmaceutical and biotech industry partners, academic institutions and other hospitals)
Job description
Job responsibilities
This is a 10 session non-training post (on the salary scale MN37, point dependent on experience) funded through The Christie NHS Foundation Trust for an initial period of 1 year (potential to extend to 2 years). The Senior Clinical fellow role is suitable for individuals towards the end of, or having completed, their specialist oncology training who wish to gain further experience in experimental medicine and Phase I trials, including first-in-human trials, clinical pharmacology trials and translational research. You will work with the experimental medicine consultants Dr Natalie Cook,Prof. Fiona Thistlethwaite, Dr Louise Carter, Dr Matt Krebs, and Dr Donna Graham, research nurses, Clinical Trials Coordinators, Translational Research Technician, secretarial support, as well as working alongside rotating clinical fellows and specialty trainees. The team is supported by medical and clinical oncology colleagues in all major tumour types.The position requires an ability to understand and deliver experimental clinical research, liaising across a range of clinical, academic and administrative staff throughout the Trust and with external organisations (pharmaceutical and biotech industry partners, academic institutions and other hospitals)
Person Specification
ATTAINMENTS Educationa
Essential
- Completion of core medical training (CMT) or acute care common Stem programme (or equivalent)
Desirable
- CCT in Medical Oncology or equivalent
- Good Clinical Practice
- Advanced Life Support
- Higher degree in cancer research
Qualifications
Essential
Professional Qualifications
Essential
Research / Publications
Essential
- Evidence of productive ethical research relevant to oncology
Desirable
- Recent publications in peer-reviewed journals Conference presentations
TRAINING
Essential
- Experience in general oncology and internal medicine
- Research/Trials experience
Desirable
- Experience in managing critically ill patients
EXPERIENCE Job Specific
Essential
- Evidence of clinical leadership skills
- Management / Audit:Experience of developing, supervising and delivering audit projects
TEACHING
Essential
- Experience in teaching undergraduates
Desirable
- Experience in teaching postgraduates
- Teaching Qualification
PERSONAL SKILLS Acceptability
Essential
- Evidence of clinical skills
- Excellent written and oral communication skills,
- flexibility, commitment and team work with colleagues and staff in the department;
- ability to work under pressure;
Desirable
- Demonstration of excellent communication skill
Person Specification
ATTAINMENTS Educationa
Essential
- Completion of core medical training (CMT) or acute care common Stem programme (or equivalent)
Desirable
- CCT in Medical Oncology or equivalent
- Good Clinical Practice
- Advanced Life Support
- Higher degree in cancer research
Qualifications
Essential
Professional Qualifications
Essential
Research / Publications
Essential
- Evidence of productive ethical research relevant to oncology
Desirable
- Recent publications in peer-reviewed journals Conference presentations
TRAINING
Essential
- Experience in general oncology and internal medicine
- Research/Trials experience
Desirable
- Experience in managing critically ill patients
EXPERIENCE Job Specific
Essential
- Evidence of clinical leadership skills
- Management / Audit:Experience of developing, supervising and delivering audit projects
TEACHING
Essential
- Experience in teaching undergraduates
Desirable
- Experience in teaching postgraduates
- Teaching Qualification
PERSONAL SKILLS Acceptability
Essential
- Evidence of clinical skills
- Excellent written and oral communication skills,
- flexibility, commitment and team work with colleagues and staff in the department;
- ability to work under pressure;
Desirable
- Demonstration of excellent communication skill
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
