Job summary
We are looking for an excellent candidate with expertise in mass spectrometry to lead our NHS UKAS-accredited diagnostic proteomics facility of the Jack O'Neill Laboratory, (JONAL).
The post-holder will work with the clinical teams under the direction of the Head of Fibril Typing and laboratory director, providing scientific and technical support to contribute to the overall activities of the Centre. They will lead and have responsibility for the supervision and training of staff and users in the daily management of the mass spectrometry facility, recruitment of new staff, sourcing and investigating options and responsibility for the purchase of equipment, with full consideration for the cost effectiveness of different solutions. They will have to develop and validate new and novel methods with mass spectrometry in line research advances.
Main duties of the job
The Proteomic Lead will be responsible to lead to provide a clinical diagnostic service and running the diagnostic proteomic facility.
They will be responsiblethe daily management and laboratory activities of the proteomics facility, training / supervising staff reporting to the Head of the Fibril Typing. Producing formal reports of service output, conduct audits, attend weekly diagnostic MDT's, being responsible for generating formal electronic reports of diagnostic proteomic results.
They will maintain proteomic laboratory accreditation, including EQA schemes, under the direction of the head of fibril typing and quality manager for the Jack O'Neill laboratory.
They will be expected to keep abreast of developments, techniques and approaches in the field of Mass Spectrometry, proteomics and bioinformatics, including new analytical tools and instruments. They will revise, validate, and implement protocols and procedures to improve diagnosis, ensuring use of the most accurate up to date diagnostic testing for optimum patient care in the delivery of high quality care, clinical governance and patient safety.
They will be required to maintain and develop collaborations at national and international level. The post holder will have an opportunity to support cutting-edge proteomics research both within the Centre and with external collaborators, including clinicians and scientists both nationally and internationally.
About us
The NHS National Amyloidosis Centre (NAC), based at the Royal Free Hospital in London, is the only centre in the UK and one of the few centres worldwide specialising in amyloidosis. It provides a comprehensive UKAS-accredited diagnostic service for the national caseload of amyloidosis patients as well as management advice and delivery of high-cost amyloid-specific therapies.
The Jack O'Neill Laboratory (JONAL) is a highly specialised laboratory which has developed dedicated methodology for the diagnosis of amyloidosis and systemic autoinflammatory diseases and is central to the NHS England-funded national highly specialised services based at the NAC. The JONAL consists of a specialised team covering specimen reception, molecular genetics, histopathology and proteomics.
Proteomics has become central to the accurate diagnosis and typing of amyloidosis and is used routinely within the Centre. The Centre continues to research and validate novel proteomic techniques for clinical diagnostic purposes as well as pursing basic science proteomic research.
Job description
Job responsibilities
Please see attached job description for more information about this role and working at Royal Free London NHS Foundation Trust.
Job description
Job responsibilities
Please see attached job description for more information about this role and working at Royal Free London NHS Foundation Trust.
Person Specification
Education & professional Qualifications
Essential
- oMSc level qualification or equivalent in chemistry, biochemistry or a related subject.
- oEvidence of continuing personal development
Desirable
- oPost graduate qualification in specific speciality or equivalent experience in proteomics.
- oRecord of scientific publication including some as first author in proteomics.
Experience
Essential
- oExtensive experience in biological and biomedical aspects of mass spectrometry including significant practical involvement in proteomics oExpertise in the performance, maintenance and operation of LC-MS instruments including Thermo Q-Exactive Plus or similar equipment. oExperience in the use of database search engines, e.g. MASCOT. oExperience of working with clinical samples, data and reporting to national organisations oExperience in Laboratory QMS and maintaining accreditation for a clinical laboratory in proteomics. oAbility to interact with scientists and clinicians as part of the development and application of mass spectrometric techniques to solve problems of clinical interest. oExperience of working in an interdisciplinary environment. oExtensive experience in training and supervising people in mass spectrometry and related techniques and in laboratory activities. oCreativity, initiative and independent working. oLeadership skills
Desirable
- oExperience in laser capture
Skills and aptitudes
Essential
- oKnowledge and understanding of mass spectrometry hardware and software oAcquired specialist expertise in using, and give guidance in clinical databases for proteomic analysis oFault finding, fixing and troubleshooting skills oKnowledge of reports and audit methodology oAbility to establish a role and develop collaborative working relationships with different teams oSkills and knowledge in managing and supporting clinical staff
Personal Qualities & attributes
Essential
- oExcellent communication, negotiation, influencing and diplomatic skills both orally and in writing oSelf-starter, motivated, able to work from own initiative and with strong attention to detail
Person Specification
Education & professional Qualifications
Essential
- oMSc level qualification or equivalent in chemistry, biochemistry or a related subject.
- oEvidence of continuing personal development
Desirable
- oPost graduate qualification in specific speciality or equivalent experience in proteomics.
- oRecord of scientific publication including some as first author in proteomics.
Experience
Essential
- oExtensive experience in biological and biomedical aspects of mass spectrometry including significant practical involvement in proteomics oExpertise in the performance, maintenance and operation of LC-MS instruments including Thermo Q-Exactive Plus or similar equipment. oExperience in the use of database search engines, e.g. MASCOT. oExperience of working with clinical samples, data and reporting to national organisations oExperience in Laboratory QMS and maintaining accreditation for a clinical laboratory in proteomics. oAbility to interact with scientists and clinicians as part of the development and application of mass spectrometric techniques to solve problems of clinical interest. oExperience of working in an interdisciplinary environment. oExtensive experience in training and supervising people in mass spectrometry and related techniques and in laboratory activities. oCreativity, initiative and independent working. oLeadership skills
Desirable
- oExperience in laser capture
Skills and aptitudes
Essential
- oKnowledge and understanding of mass spectrometry hardware and software oAcquired specialist expertise in using, and give guidance in clinical databases for proteomic analysis oFault finding, fixing and troubleshooting skills oKnowledge of reports and audit methodology oAbility to establish a role and develop collaborative working relationships with different teams oSkills and knowledge in managing and supporting clinical staff
Personal Qualities & attributes
Essential
- oExcellent communication, negotiation, influencing and diplomatic skills both orally and in writing oSelf-starter, motivated, able to work from own initiative and with strong attention to detail
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
