Job summary
CLINICAL RESEARCH FELLOW IN PAEDIATRIC ONCOLOGY for THE UMBRELLA PLUS RENAL TUMOUR STUDY UK
ONE POST Available (ST4 +)
36 months fixed term (possibility to extend)
This post will play a key role in the Developmental Biology and Cancer program at GOSH together with the Genetics and Genomics Medicine program at the Wellcome Sanger Institute which aims to improve the delivery of a personalised treatment plan for all children with renal tumours in the UK based on individual tumour and germline genetics. The Umbrella Plus Research fellow will be part of a team of doctors, study manager, research assistants and data manager and will be based at Great Ormond Street Hospital for Children. This 36-month Clinical Research Fellow post is particularly suited for a paediatric trained doctor (ST4 or equivalent) who has Paediatric Oncology experience (at least 1 year) and completed MRCPCH (or equivalent international paediatric training), and has experience in analysing genetic data from tumours especially whole genome sequencing.
The post is to provide clinical and genomic expertise to support the full time members of staff who coordinate UK UMBRELLA PLUS projects working with Dr Tanzina Chowdhury, Professor Sam Behjati and Professor Pritchard-Jones.
This post is due to commence in as soon as possible and by the 1st November 2024.
Main duties of the job
The post-holder will:
o Coordinate consent for Whole Genome Sequencing for all renal tumour patients registered in the UMBRELLA PLUS study from centres in England, or whose samples can be transferred to English centres for consent and analysis
o Coordinating the analysis of WGS data in the context of the outputs of renal tumour molecular and genomic data from The Little Princess Knowledge Bank of Wilms Tumours in collaboration with investigators from the Wellcome Sanger Institute
o Coordinate with the UMBRELLA PLUS team and the PTC lead clinician for the patient a bespoke real-time discussion of the molecular data and its imapct on patient diagnosis, acute management and future surveillance
o Coordinate at GOSH the clinical and radiological review of renal tumour patients registered in the UMBRELLA PLUS study from centres in the UK and Republic of Ireland
o Liaise with international members of the European SIOP Renal Tumours Study Group (SIOP-RTSG) to develop guidelines and inform the next European UMBRELLA protocol.
About us
GOSH is committed to recruiting the best person for the job, based solely on their ability and individual merit as measured against the criteria for the role; through a process that is fair, open, consistent and free from bias and discrimination.
We are committed to being a diverse and inclusive employer and foster a culture where all staff are valued, respected and acknowledged. All applicants will receive consideration for employment without regard to race, colour, national origin, religion, sexual orientation, gender, gender identity, age, disability status or length of time spent unemployed.
We particularly welcome applications from BAME communities, people with disabilities and/or long-term health conditions and LGBT+ community members.
We have policies and procedures in place to ensure that all applicants and employees are treated fairly and consistently. We are proud to be accredited as a Disability Confident Employer, a member of Business Disability Forum and a Stonewall Diversity Champion.
We have active and Executive supported BAME, LGBT+ and Allies, Disability and Long-Term Health Conditions and Women's staff networks. Staff networks are employee-led groups formed around interests, issues and a common bond or background. Staff network members create a positive and inclusive work environment at Great Ormond Street Hospital by actively contributing to the Trust's mission, values and efforts specific to inclusion. All of our staff networks are open to any employee.
Job description
Job responsibilities
The full job description provides an overview of the key tasks and responsibilities of the role, and the person specification outlines the qualifications, skills, experience and knowledge required. For both documents please view the attachments.
Job description
Job responsibilities
The full job description provides an overview of the key tasks and responsibilities of the role, and the person specification outlines the qualifications, skills, experience and knowledge required. For both documents please view the attachments.
Person Specification
GOSH Culture and Values
Essential
- Always welcoming
- Always helpful
- Always expert
- Always one team
- Highly motivated and a strong desire for excellence
- Excellent attention to detail
- Ability to work as part of a multidisciplinary team
- Excellent oral and written communication skills
Experience/Knowledge
Essential
- Previous clinical experience in paediatric oncology or experience of acute adult or paediatric haematology
- Experience of analysing genetic data from tumours especially whole genome sequencing
- Familiarity with principles of evidence-based medicine
- Understanding of treatment protocols and clinical trial conduct in field of childhood cancer.
Desirable
- Previous research outputs including publications and research grants
- Good Clinical Practice (GCP) training
- Practical experience in enrolling/managing children on clinical trials
Skills/Abilities
Essential
- Ability to work both independently and as part of different teams
- Proficient core computer skills
- Basic coding skills in R
- Organised and methodical approach to upkeep of data
- Ability to prioritise work to meet multiple deadlines
Desirable
Academic/Professional qualification/Training
Essential
- Medical degree and either post graduate qualification in paediatrics (MRCPCH or equivalent level in an area relevant to the multi-disciplinary team involved in childhood cancer)
- Clinical experience in childhood cancer or a related discipline from the multi-disciplinary team involved in oncology
- Full GMC registration with Licence to Practice or IELTS Certificate with an overall score of 7.5 or Occupational English Test (medicine version) with a minimum score of 'B' in each domain.
Desirable
- Post graduate research degree
Person Specification
GOSH Culture and Values
Essential
- Always welcoming
- Always helpful
- Always expert
- Always one team
- Highly motivated and a strong desire for excellence
- Excellent attention to detail
- Ability to work as part of a multidisciplinary team
- Excellent oral and written communication skills
Experience/Knowledge
Essential
- Previous clinical experience in paediatric oncology or experience of acute adult or paediatric haematology
- Experience of analysing genetic data from tumours especially whole genome sequencing
- Familiarity with principles of evidence-based medicine
- Understanding of treatment protocols and clinical trial conduct in field of childhood cancer.
Desirable
- Previous research outputs including publications and research grants
- Good Clinical Practice (GCP) training
- Practical experience in enrolling/managing children on clinical trials
Skills/Abilities
Essential
- Ability to work both independently and as part of different teams
- Proficient core computer skills
- Basic coding skills in R
- Organised and methodical approach to upkeep of data
- Ability to prioritise work to meet multiple deadlines
Desirable
Academic/Professional qualification/Training
Essential
- Medical degree and either post graduate qualification in paediatrics (MRCPCH or equivalent level in an area relevant to the multi-disciplinary team involved in childhood cancer)
- Clinical experience in childhood cancer or a related discipline from the multi-disciplinary team involved in oncology
- Full GMC registration with Licence to Practice or IELTS Certificate with an overall score of 7.5 or Occupational English Test (medicine version) with a minimum score of 'B' in each domain.
Desirable
- Post graduate research degree
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
