Job summary
We are seeking an enthusiastic and dynamic individual for the post of Clinical Research Fellow in Skeletal Dysplasia to join our dynamic and friendly Paediatric Genetics Research team at Guy's and St Thomas NHS Foundation Trust.
This post is an exciting opportunity for a specialist trainee (ST3-ST5 grade) who would like to undertake a period of clinical research within skeletal dysplasia field in a large tertiary centre.
Main duties of the job
The successful candidate will provide sub-investigator and medical support working on a variety of commercially sponsored clinical trials in achondroplasia and skeletal dysplasia, and the metaphyseal chondrodysplasia type Schmid (MCDS) drug repurposing trial. They will also be assisting in an exciting project to investigate the application of novel bioinformatics algorithms, deep phenotyping and machine learning approaches to identify novel disease genes and mechanisms for musculoskeletal patients (MSK) in the Genomics England (GeL) 100,000 Genomes Project (100KGP). This is supported by an MRC grant to facilitate solving undiagnosed cases submitted to 100KGP with unexplained skeletal dysplasia.
The majority of this work (commercial trials and MCDS trial) will be undertaken at the Evelina and at St Thomas', with some off-site working where required. The 100K GECIP activities will be conducted remotely and at Guy's Hospital in clinical genetics. This will entail reanalysis of both phenotypic and genotype data and collaboration with the team in Oxford, attending MDM on a monthly basis, liaising with Genomics England and other Genomic Medicine Centres to access data (in accordance with the established 100K governance framework).
About us
The successful candidate will be joining a dynamic, hardworking and supportive team of research nurses, coordinators, clinical research practitioners and clinical investigators, covering novel and exciting clinical research trials within paediatric genetics and skeletal dysplasia team. The team focus on high-quality holistic care to children and young people participating in the paediatric genetic research portfolio.
Working within Specialist Ambulatory Service and Evelina Paediatrics Genetics Research, we aim to deliver safe clinical trials to children with rare diseases.
Job description
Job responsibilities
Please see attached Job Description and Person Specification for this role. Please ensure that you use the person specification to inform your supportive statement during application and use current examples of where you meet the essential and desirable criteria.
Job description
Job responsibilities
Please see attached Job Description and Person Specification for this role. Please ensure that you use the person specification to inform your supportive statement during application and use current examples of where you meet the essential and desirable criteria.
Person Specification
Qualifications/ Education
Essential
- MBBS
- Full registration with GMC
Desirable
Previous experience
Essential
- Research experience
- Experience of team and MDT working
- Evidence of presentations, posters and publications
- Experience in data processing
Desirable
- Research in relevant specialty to role
- Commercial trial experience
- Experience in collecting and processing biological samples
- Experience working with paediatric patients
Skills/Knowledge/ Ability
Essential
- A broad knowledge and understanding of the specialty
- Leadership qualities
Desirable
- Active interest in research and audit
Person Specification
Qualifications/ Education
Essential
- MBBS
- Full registration with GMC
Desirable
Previous experience
Essential
- Research experience
- Experience of team and MDT working
- Evidence of presentations, posters and publications
- Experience in data processing
Desirable
- Research in relevant specialty to role
- Commercial trial experience
- Experience in collecting and processing biological samples
- Experience working with paediatric patients
Skills/Knowledge/ Ability
Essential
- A broad knowledge and understanding of the specialty
- Leadership qualities
Desirable
- Active interest in research and audit
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
